Obesity, diabetes, and risk of Parkinson's disease
Identifieur interne : 000224 ( Main/Exploration ); précédent : 000223; suivant : 000225Obesity, diabetes, and risk of Parkinson's disease
Auteurs : Natalia Palacios [États-Unis] ; Xiang Gao [États-Unis] ; Marjorie L. Mccullough [États-Unis] ; Eric J. Jacobs [États-Unis] ; Alpa V. Patel [États-Unis] ; Tinisha Mayo [États-Unis] ; Michael A. Schwarzschild [États-Unis] ; Alberto Ascherio [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
English descriptors
- KwdEn :
Abstract
The aim of this work was to investigate whether obesity and diabetes are related to risk of Parkinson's disease. We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of Parkinson's disease (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted Parkinson's disease risk. Relative risk comparing individuals with a baseline body mass index of ≥30 to those with a body mass index <23 was 1.00 (95% confidence interval: 0.75, 1.34; P trend: 0.79), and that comparing individuals with a waist circumference in the top category (≥40.3 inches in men and ≥35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% confidence interval: 0.95, 1.93; P trend: 0.08). History of diabetes was not significantly associated with Parkinson's disease risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; P heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with Parkinson's disease risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23855
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Obesity, diabetes, and risk of Parkinson's disease</title><author><name sortKey="Palacios, Natalia" sort="Palacios, Natalia" uniqKey="Palacios N" first="Natalia" last="Palacios">Natalia Palacios</name></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name></author><author><name sortKey="Mccullough, Marjorie L" sort="Mccullough, Marjorie L" uniqKey="Mccullough M" first="Marjorie L." last="Mccullough">Marjorie L. Mccullough</name></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V." last="Patel">Alpa V. Patel</name></author><author><name sortKey="Mayo, Tinisha" sort="Mayo, Tinisha" uniqKey="Mayo T" first="Tinisha" last="Mayo">Tinisha Mayo</name></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0A</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23855</idno><idno type="url">https://api.istex.fr/document/671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0A/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000A89</idno><idno type="wicri:Area/Main/Curation">000952</idno><idno type="wicri:Area/Main/Exploration">000224</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Obesity, diabetes, and risk of Parkinson's disease</title><author><name sortKey="Palacios, Natalia" sort="Palacios, Natalia" uniqKey="Palacios N" first="Natalia" last="Palacios">Natalia Palacios</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mccullough, Marjorie L" sort="Mccullough, Marjorie L" uniqKey="Mccullough M" first="Marjorie L." last="Mccullough">Marjorie L. Mccullough</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V." last="Patel">Alpa V. Patel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Mayo, Tinisha" sort="Mayo, Tinisha" uniqKey="Mayo T" first="Tinisha" last="Mayo">Tinisha Mayo</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2253">2253</biblScope><biblScope unit="page" to="2259">2259</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0A</idno><idno type="DOI">10.1002/mds.23855</idno><idno type="ArticleID">MDS23855</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>body mass index</term><term>diabetes</term><term>obesity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this work was to investigate whether obesity and diabetes are related to risk of Parkinson's disease. We prospectively followed 147,096 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Participants provided information on anthropometric variables and medical history at baseline and on waist circumference in 1997. Incident cases of Parkinson's disease (n = 656) were confirmed by treating neurologists and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Neither body mass index nor waist circumference significantly predicted Parkinson's disease risk. Relative risk comparing individuals with a baseline body mass index of ≥30 to those with a body mass index <23 was 1.00 (95% confidence interval: 0.75, 1.34; P trend: 0.79), and that comparing individuals with a waist circumference in the top category (≥40.3 inches in men and ≥35 inches in women) to those in the bottom category (<34.5 inches in men and <28 inches in women) was 1.35 (95% confidence interval: 0.95, 1.93; P trend: 0.08). History of diabetes was not significantly associated with Parkinson's disease risk (combined relative risks = 0.88; 95% confidence interval: 0.62, 1.25; P heterogeneity = 0.96). In addition, neither body mass index at age 18 nor changes in weight between age 18 and baseline were significantly associated with Parkinson's disease risk. The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Palacios, Natalia" sort="Palacios, Natalia" uniqKey="Palacios N" first="Natalia" last="Palacios">Natalia Palacios</name></region><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name><name sortKey="Mayo, Tinisha" sort="Mayo, Tinisha" uniqKey="Mayo T" first="Tinisha" last="Mayo">Tinisha Mayo</name><name sortKey="Mccullough, Marjorie L" sort="Mccullough, Marjorie L" uniqKey="Mccullough M" first="Marjorie L." last="Mccullough">Marjorie L. Mccullough</name><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V." last="Patel">Alpa V. Patel</name><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000224 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000224 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:671E5CAD25D7E12AF929A636B8CC1CBF3A7BFA0A
|texte= Obesity, diabetes, and risk of Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |